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DNA: Francis Crick

Currency:USD Category:Collectibles / Autographs Start Price:NA Estimated At:1,500.00 - 2,000.00 USD
DNA: Francis Crick

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Auction Date:2015 May 13 @ 18:00 (UTC-5 : EST/CDT)
Location:236 Commercial St., Suite 100, Boston, Massachusetts, 02109, United States
ALS - Autograph Letter Signed
ANS - Autograph Note Signed
AQS - Autograph Quotation Signed
AMQS - Autograph Musical Quotation Signed
DS - Document Signed
FDC - First Day Cover
Inscribed - “Personalized”
ISP - Inscribed Signed Photograph
LS - Letter Signed
SP - Signed Photograph
TLS - Typed Letter Signed
Two TLSs: a TLS signed “Francis Crick,” one page, 8.5 x 11, The Salk Institute letterhead, September 22, 1977. Letter of recommendation for Dr. Hans Joachim Lipps. In part: “Dr. Hans Lipps has asked me to write a few words in support of his proposal to study the molecular biology of ciliates with especial reference to gene regulation…I know Dr. Lipps personally since he has worked at my old laboratory…he has an excellent grasp of the opportunities and difficulties of working on ciliates…and a good idea of problems of general importance, not merely for ciliates but for eucaryotes in general…this sort of work on ciliates is a neglected field and deserves more support. No doubt ciliates are not quite the same as most other eucaryotes, but then the phages T4 and ? are not the same as a typical procaryote. This has not meant that they have proved of no value for fundamental biological research. Ciliates may prove to be equally as useful.” The second TLS of the same date, signed “Francis,” is the transmittal letter to Dr. Lipps for this recommendation. In overall fine condition, with light creases. Lipps did eventually get funding for his studies of ciliates and published a well-known paper in 1996, ‘Macronucleus structure and macronucleus development in hypotrichous ciliates,’ in which he explains how studying ciliates provides an unusual opportunity to study the ways in which DNA sequences can be manipulated in a differentiating cell. Crick’s understated closing remark on the importance of “phages T4 and ?” should not go unnoticed—it was in observing mutations of the T4 phage that Crick demonstrated the triplet nature of the genetic code, one of the steps along the way to understanding DNA structure.